The concomitant use of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors could result in a rise in methadone plasma concentrations, which could trigger possibly deadly respiratory melancholy. On top of that, discontinuation of concomitantly utilized cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers can also lead to a rise in me